The Reactions of a Purified Timothy Allergen with Rabbit Antiserum and with Serum and Leucocytes of Allergic Patients

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Abstract
The characteristics of reaction between a partially purified timothy antigen and rabbit and human antisera were studied with the aid of radioiodine labeled antigen. Rabbits hyperimmunized with whole pollen produced only a very small amount of antibody to the purified antigen. This low antigenicity may be explained by rapid elimination of the antigen by glomerular filtration. No antibody was found in the sera of untreated timothy-allergic patients although some antibody appeared after therapeutic injections of timothy pollen. Antigen was not found bound to leukocytes of untreated timothy-sensitive patients.