Blood-brain barrier integrity in patients with cerebral infarction investigated by computed tomography and serum-CSF-albumin

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Abstract
Measurements of CSF-albumin, and S[serum]/CSF-albumin in 2 groups of patients with small and large infarcts failed to show BBB [blood-brain-barrier] damage to albumin .apprx. 1/2 of the patients. No significant difference was found between the 2 groups of patients in regard to the above-mentioned parameters. The localication of the infarcts (close to the CSF or deep in the brain) did not influence the S/CSF-albumin. No correlation was found between the S/CSF-albumin and the time interval between the onset of the stroke and the lumbar puncture within 96 h. Some suggestions are put forward to explain the discrepancies between the computed tomography scan and S/CSF-albumin in the assessment of BBB damage.