Lack of Predictive Value of Antileukocyte Antibody Screening in Granulocyte Transfusion Therapy

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Abstract
To clarify the relationship between recipient presensitization and response to granulocyte (PMN [polymorphonuclear]) transfusion, 187 non-HLA matched donor-recipient pairs were tested for the presence of antileukocyte antibody using granulocytotoxicity (G), lymphocytotoxicity (L), microleukoagglutination (M) and capillary leukoagglutination (C) assays. PMN increments per 1011 transfused PMN per square area, ascertained 1 h following termination of transfusion, and the occurrence of nonhemolytic transfusion reactions were correlated with the assay results. Although circulating anti-donor-leukocyte antibody was detected in 52% of recipients, there was no statistically significant relationship between the presence of these antibodies and PMN recovery or incidence of transfusion reaction. The prospective use of these assays is of little value in predicting the recipient''s response to PMN transfusion.