Quantitative alterations in the nucleolar and nucleoplasmic ribosomal ribonucleic acids in regenerating rat liver

Abstract
A quantitative analysis of the nuclear pre-rRNA (precursor to rRNA) and rRNA in normal and 12 h-regenerating rat liver was carried out and the absolute amounts of the identified pre-rRNA and rRNA species in the nucleolus and nucleoplasm were determined. Characteristic changes in the pre-rRNA and rRNA pool sizes in regenerating liver were found which revealed alterations in both pre-rRNA processing and nucleocytoplasmic transition of ribosomes.