Physiological activity of streptothricin antibiotics.

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Abstract
The physiological activities of streptothricin antibiotics were investigated, using racemomycin-D as a representative of the group. Racemomycin-D showed a weak but broad-spectrum insecticidal activity against the adults of Blattella germanica, Musca domestica, Nilaparvata lugens, Laodelphax striatella and Plutella xylostella. A rather strong insecticidal effect on Culex pipiens molestus larvae was found, with mortalities of 90% and 15% at 10 ppm and 2 ppm, respectively. Though racemomycin-D showed no insecticidal effect against the larvae of Spodoptera litura, it showed inhibitory activity on feeding at a concentration of 300 ppm. Racemomycin-D was toxic to all the fish species examined, i.e., Misgurnus anguillicaudatus, Carassius auratus and Oryzias latipes. Among these, racemomycin-D showed particularly strong toxicity against C. auratus with a TLm [median tolerance limit] of 3.7 ppm (after 48 h). Racemomycin-D showed strong inhibitory activity on the growth of Brassica campestris ssp. napus var. nippo-okifera, Arctium lappa, Petroselinum sativum and Raphanus sativus var. acanthiformis at a concentration of 500 ppm (with an inhibitory ratio of 0.1, relative to 1.0 for the control group).