Immunological Tolerance Induced in Animals Previously Sensitized to Simple Chemical Compounds
- 15 May 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 144 (3620) , 853-854
- https://doi.org/10.1126/science.144.3620.853
Abstract
Adult guinea pigs develop a delayed hypersensitivity to intradermally injected neoarsphenamine. If the animals are treated intravenously with high doses of this compound before sensitization, a specific and permanent immunological tolerance develops. Permanent tolerance is also obtained in previously sensitized animals when an intravenous injection of neoarsphenamine isfollowed 6 hours later by an intradermal one. When, however, the interval between the two injections is extended to 7 or 14 days, no tolerance is observed.Keywords
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