Immunological Unresponsiveness Produced in Adult Guinea Pigs by Parenteral Introduction of Minute Quantities of Hapten or Protein Antigen.

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Abstract
Delayed hypersensitivity and circulating antibody production to a hapten (picryl chloride) and to a protein antigen (bovine gamma globulin) were regularly suppressed in mature guinea pigs injected twice into mesenteric veins prior to sensitization, with hapten or protein in gamma amounts.