IMMUNOLOGIC UNRESPONSIVENESS INDUCED BY PROTEIN ANTIGENS

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Abstract
1. Repeated large infusions of heterologous plasma proteins can induce a state of specific immunologic unresponsiveness in rabbits. In normal adult rabbits this unresponsiveness in most instances lasts only about as long as the heterologous proteins are detectable in the host (3 to 4 months). In rabbits infused from the time of birth and perhaps x-radiated adult rabbits the induced immunologic unresponsiveness lasted throughout the period of observation (10 to 11 months), long after disappearance of all detectable foreign proteins.