Acetate utilization by the isolated perfused guinea-pig mammary gland

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Abstract
Summary: Acetate uptake by isolated perfused guinea-pig mammary glands was approximately l·0 mg g−1h−1when perfusate acetate concentrations were in the physiological range (5–11 mg/100 ml plasma). At perfusate concentrations below this range (mean 3·62 mg/100 ml plasma) the uptake was not significantly different, but in one experiment in which the mean acetate concentration was 14·5 mg/100 ml plasma the uptake was markedly elevated. Radioactivity from Na [1-14C]acetate was incorporated into CO2and milk and tissue fat, being largely present in C16and C18fatty acids. The guinea-pig is atypical of non-ruminants and similar to ruminants in respect of the blood concentration and mammary utilization of acetate.

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