Activation of chloride channels in the plasmalemma of Nitella syncarpa by inositol 1,4,5‐trisphosphate

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Abstract
The introduction of 1.5 × 10−8 − 10−6 M inositol 1,4,5‐trisphosphate (IP3) into the bathing solution of Nitella syncarpa cells induced: (i) an increase in amplitude of the inward Ca2+ current; (ii) the appearance of an inward Cl− current; (iii) a shift in the threshold for activation of the Cl− channels on hyperpolarization of the membrane to more positive values. These facts suggest that IP3 participates in the causing of changes in the intracellular free Ca2+ concentration and, hence, in the regulation of ionic channels in Nitella syncarpa plasmalemma.