EFFECTS OF ORAL ADMINISTRATION OF THIOURACIL ON THE METABOLISM OF ISOLATED TISSUES FROM NORMAL AND HYPERTHYROID RATS

Open Access
Publisher Website
Google Scholar
Abstract
The rate of O2 consumption of the thyroids, adrenals, livers and diaphragm muscles of rats treated with thiouracil orally and for thyrotrophic hormone subcut. was detd. The respiration of the thyroid is increased by both drugs; the effect of their combination is greater than that of either alone. The adrenals show little change with either drug alone; both together produce an increase in immature but not in mature animals. The respiration of liver and muscle is not influenced by thiouracil ; the stimulation by thyrotrophic hormone is abolished by simultaneous adm. of thiouracil. The results are discussed in terms of a compensatory hypertrophy of the thyroid gland due to the inhibition by thiouracil of the formation of thyroid hormone.