ACTION OF CERTAIN SULFONAMIDES AND OF THIOUREA UPON THE FUNCTION OF THE THYROID GLAND OF THE RAT1

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Abstract
GOITER changes in the thyroid gland have been observed to follow a variety of experimental conditions. A century ago iodine was used in the treatment of thyroid enlargement and it has become well established that hyperplastic goiters ensue when the dietary iodine is reduced below a certain level. Although iOdine deficiency is said to be the commonest cause of thyroid hyperplasia in the human being and in experimental animals, a great many agents have been seen to cause a similar thyroid effect in such animals as rodents, ungulates, birds,fishand man. Reference to the extensive literature on this subject shows that the following agents have, under the conditions of the several experiments, induced thyroid enlargement: high protein diets (1–5), diets containing a large proportion of liver (4–7), fat (5), soybeans (8), or calcium salts (9–11), polluted water, bacterial cultures, fecal filtrates and filtrates from cultures of anerobic bacteria (12), diets composed largely of cabbage or related greens (13,14), the feeding of the seeds of several species of Brassicae (15) and the administration of various nitriles, especially methylcyanide (16), arsenic salts (17) and thiocyanates (18–20).

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