Production of Goiter in Rats with Raw and with Treated Soy Bean Flour

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Abstract
A diet composed of unprocessed soy bean flour, yeast, sugar, butterfat, sodium chloride and calcium carbonate, when fed to rats, produces thyroid enlargement of four times normal in an experimental period of 7 weeks. The minimum iodine requirement of rats fed the goiterogenic diet is two times normal or approximately 50 μg. per 100 calories of food. The optimum iodine requirement is approximately 200 μg per 1000 calories which is also twice normal. Unprocessed soy bean flour contains a positive goiterogenic property that is removed or destroyed by fat solvents (ether or acetone) or by steam.