A Study of the Effect of Vitamin B and Iodine on the Weight, Iodine Content and Structure of the Thyroid Gland of the Rat

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Abstract
Vitamin B deficiency alone did not affect the size, structure, or iodine content of the thyroid gland of the rat. Rats fed a diet deficient in vitamin B and containing 0.0038% iodine developed a thyroid gland that microscopically simulated colloid goiter. This condition did not develop when the diet contained 0.019% iodine or vitamin B. The results suggest that some factor present in yeast which is lost when the yeast is autoclaved and which is not supplied by a vitamin B containing extract causes an increase in the iodine content and concentration of the thyroid. Differences in the weight of the hypophysis of rats on the different diets were not statistically significant.

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