The Conjunctival Sickling Sign, Hemoglobin S, and Irreversibly Sickled Erythrocytes

Abstract
• Sixty-five patients with hemoglobins AS, SC, and SS were investigated in a masked fashion. We observed a statistically significant positive correlation between the severity of conjunctival sickling signs and the counts of irreversibly sickled cells in each hemoglobinopathy group. We also observed a statistically significant positive correlation between the severity of the conjunctival vasculopathy and the percentage of sickle hemoglobin in the total group of patients with hemoglobins AS, SC, and SS. (Arch Ophthalmol 95:808-811, 1977)

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