An Analysis of the Role of Dose and Dosage Rate in the Early Radiation Mortality of the Chick

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Abstract
The relation between dose, dose rates and mortality in young chicks (3-4 days after hatching) is examined. Based on empirical relationships observed between first period (0-2 days) mortality in the chick under C06O gamma-irradiation and both dosage and exposure time, a working model of radiation effects during exposure, that may lead to mortality within this period in the chick, is devised. Hypotheses are: (1) Exposure produces an Effect (Y) that accrues at a rate proportional to the dosage rate, i.e., [image] where D is the delivered dosage and [mu] > 0 is a constant scale factor relating dose to effect; (2) The Effect (Y) is reversed by chick i at a constant rate Bi or at the rate of accrual, whichever is smaller; (3) Death within 2 days following irradiation occurs if the net amount Y[image]i (t) of Effect (Y) accumulated reaches, in chick i, the value Yoi; (4) For a given population of chicks, Bi and Yoi are approximately normally distributed with ratios of corresponding parameters equal to a constant K. Variation in dosage rate affects mortality in the 2nd period (3-12 days) in a different manner.

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