ATTEMPTS TO INDUCE MENSTRUATION BY OPERATIVE ISCHEMIA IN MONKEYS

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Abstract
In a group of ovariec-tomized rhesus monkeys treated with estrogenic hormones the circulation to the body of the uterus was completely interrupted for periods varying from l-81/4 hrs. (in 2 cases for 19 hrs.). This procedure did not precipitate macroscopic uterine bleeding, nor did it hasten the onset of an expected bleeding following estrogen withdrawal. When interruption of the uterine circulation was maintained for periods longer than 3 hrs., an increasing impairment of the bleeding response to estrogen withdrawal was observed. In 3 animals the uterus survived an 8-hr. period of ischemia with subsequent return of the bleeding response to estrogen withdrawal and only slight morphological evidence of persistent damage ischemia of the whole uterus will not precipitate uterine bleeding. This does not invalidate the theory that ischemia limited to the endometrium is an essential antecedent to hemorrhage in normal and exptl. menstruation.

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