Nitrotyrosine as a marker for peroxynitrite‐induced neurotoxicity: the beginning or the end of the end of dopamine neurons?
- 22 March 2004
- journal article
- review article
- Published by Wiley in Journal of Neurochemistry
- Vol. 89 (3) , 529-536
- https://doi.org/10.1111/j.1471-4159.2004.02346.x
Abstract
This review examines the involvement of nitrotyrosine as a marker for peroxynitrite-mediated damage in the dopamine neuronal system. We propose that the dopamine neuronal phenotype can influence the cytotoxic signature of peroxynitrite. Dopamine and tetrahydrobiopterin are concentrated in dopamine neurons, and both are essential for their proper neurochemical function. It is not well appreciated that dopamine and tetrahydrobiopterin are also powerful blockers of peroxynitrite-induced tyrosine nitration. What is more, the reaction of peroxynitrite with either dopamine or tetrahydrobiopterin forms chemical species (i.e. o-quinones and pterin radicals, respectively) whose cytotoxic effects may be manifested far earlier than nitrotyrosine formation in the course of dopamine neuronal damage. A better understanding of how the dopamine neuronal phenotype modulates the effects of reactive nitrogen species could reveal early steps in drug- and disease-induced damage to the dopamine neuron and form the basis for rational, protective therapies.Keywords
This publication has 84 references indexed in Scilit:
- Tetrahydrobiopterin Prevents Nitration of Tyrosine Hydroxylase by Peroxynitrite and Nitrogen DioxideMolecular Pharmacology, 2003
- Dopamine Prevents Nitration of Tyrosine Hydroxylase by Peroxynitrite and Nitrogen DioxidePublished by Elsevier ,2003
- Oxidative stress in Parkinson's diseaseAnnals of Neurology, 2003
- Transmembrane Nitration of Hydrophobic Tyrosyl PeptidesPublished by Elsevier ,2003
- Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitriteThe FASEB Journal, 2001
- The role of tetrahydrobiopterin in the activation of oxygen by nitric-oxide synthaseJournal of Inorganic Biochemistry, 2000
- Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial FunctionBiochemical and Biophysical Research Communications, 1999
- Antibodies from patients with Parkinson's disease react with protein modified by dopamine oxidationJournal of Neuroscience Research, 1998
- Inhibition of Peroxynitrite-Mediated Tyrosine Nitration by Catechin PolyphenolsBiochemical and Biophysical Research Communications, 1997
- Peroxynitrite‐mediated oxidative protein modificationsFEBS Letters, 1995