Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother‐to‐child transmission of HIV
- 19 March 2007
- journal article
- clinical trial
- Published by Wiley in Environmental and Molecular Mutagenesis
- Vol. 48 (3-4) , 322-329
- https://doi.org/10.1002/em.20266
Abstract
Zidovudine‐based antiretroviral therapies (ARTs) for treatment of HIV‐infected pregnant women have markedly reduced mother‐to‐child transmission of the human immunodeficiency virus (HIV‐1) from ∼25% to P = 0.006) and 0.12 ± 0.02 in control cord bloods (P < 0.0001). %MN‐RET in ZDV‐exposed newborns decreased over the first 6 months of life to levels comparable to cord blood controls. These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long‐term monitoring of HIV‐uninfected ZDV‐exposed infants isrecommended to ensure their continued health. Environ. Mol. Mutagen. Published 2007 Wiley‐Liss, Inc.Keywords
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