Acetylation of collagen

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Abstract
In mildly alkaline suspension collagen is acetylated by acetic anhydride at the free amino groups. The number of N-acetyl groups introduced is equal to the total number of lysine and hydroxylysine residues found by analysis. Dry collagen does not react with cold acetic anhydride, but in the presence of acetic acid or of small amts. of water both N- and O-acetylation take place. The reaction is a slow one and is catalyzed by acetic acid or indirectly, by water. At its completion all the epsilon-amino groups and about 77% of the hydroxy-amino-acid residues of the protein have reacted.

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