Inhibition of association vs. dissociation of high-avidity DNA/Anti-DNA Conplexes: Possible involvement of secondary hydrogen bonds
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Immunological Investigations
- Vol. 14 (3) , 245-253
- https://doi.org/10.3109/08820138509076148
Abstract
Recent results on the conditions of ionic strength needed to prevent the association of dsDNA with high avidity human anti-dsDNA, were compared with the insufficiency of even the highest practicable ionic strengths to effect the dissociation of such antigen-antibody complexes, once formed (1). Further analysis of these results make us conclude that such high avidity dsDNA-anti-dsDNA complexes. which in the initial stages of their formation are mainly of the Coulombic variety. subsequently evolve, at least in part, into hydrogen bonds.Keywords
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