The Effect of Total Body X-Irradiation on Hepatic and Renal Function in Albino Rats

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Abstract
One hundred and fifty rats received a single dose of X-irradiation (806 r and 600 r). Two irradiated rats and one control rat were sacrificed each day. Liver slices were incubated with antidiuretic hormone (ADH) in Locke solution at 26[degree]C for 1 hour, and the antidiuretic activity of the solution bioassayed by Burn''s method. Only 3 of 63 irradiated rats (5%) lost their capacity to inactivate ADH. No change of prothrombin time and histological structure of liver slices was observed. The p-aminohippuric acid uptake and oxygen consumption by the kidney slices were slightly less than the daily control in the first 12 days post-irradiation. They then returned to normal. Creatinine and p-aminohippuric acid clearances were determined in 7 male rats. In 2 of them CCR and CpAH were reduced after irradiation.