THE INFLUENCE OF GLYCINE ON THE EXCRETION OF CREATINE AND CREATININE

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Abstract
Of 80 subjects in miscellaneous and myasthenia grayis groups, 80% excreted extra creatine after the administration of glycine, although the excretion of creatine and creatinine in many had previously been normal. In all progressive muscular dystrophy subjects glycine caused increased creatine excretion. Only indefinite and inconsistent changes were produced in the tolerance of subjects who had normally had a low creatine tolerance. The magnitude of increase in creatine excretion caused by glycine, the time before initial increase occurred, and the subsequent rate of increase during continued administration of glycine varied widely. After max. excretion of creatine was reached, most of the subjects maintained it as long as the glycine was administered. In most cases glycine produced no change in the excretion of creatinine. Glutamic acid was relatively ineffective in increasing creatine excretion.

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