THE EXCRETION OF URINE IN THE DOG

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Abstract
In normal dogs to which creatinine has been administered the creatinine clearance exceeds the xylose (glomerular) clearance by 15-40% [10 exps. on 10 dogs cited]. This excessive excretion of creatinine is interpreted as due to the tubular secretion of this substance from the post-glomerular blood. The tubular secretion of creatinine appears to be a linear function of the plasma cone, below 50 mgm. %, and therefore the tubular clearance is independent of the plasma conc. It follows that the total creatinine clearance is likewise independent of the plasma conc. Changes in the glomerular clearance effected by diet and erythroltetranitrate are accompanied by nearly proportional changes in the same direction in the creatinine clearance, indicating that the former are accompanied by nearly proportional changes in blood flow to the tubules. Phlorhizin completely arrests the tubular secretion of exogenous creatinine so that the total creatinine clearance is reduced to the level of the xylose (or glucose) clearance.

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