Inhibitory effects of 3′‐methyl‐3‐hydroxy‐chalcone on proliferation of human malignant tumor cells and on skin carcinogenesis

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Abstract
3′‐methyl‐3‐hydroxy‐chalcone (3Me‐3‐C), a derivative of chalcone, inhibited the proliferation of various kinds of human malignant tumor cells, such as HGC‐27 (gastric cancer), HeLa (cervical carcinoma), PANC‐1 (pancreatic cancer) and GOTO (neuroblastoma). Flow‐cytometric analysis of HGC‐27 cells revealed that 3′Me‐3‐C perturbed the cell cycle, i.e., it delayed passage through the S phase, and/or caused arrest in the G0/G1 phase. 3′Me‐3‐C inhibited the binding of [6,7‐3H]estradiol to type‐II estrogen‐binding sites dose‐dependently, and altered the pattern of protein synthesis and phosphorylation, which may explain 3Me‐3‐C‐induced inhibition of cell proliferation. In addition, 3Me‐3‐C also suppressed the promoting activity of 12‐0‐tetradecanoylphorbol‐13‐acetate on skin carcinogenesis in 7,12‐dimethylbenz[a]anthracene‐initiated mice.