Experimental Cerebral Fat Embolism

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Abstract
Injection of radioactive fat emboli into the internal carotid artery of rabbits resulted in rapid death in some animals. Death was preceded by hypertension and Cheyne-Stokes respirations. These animals showed an increased retention of fat emboli within the brain, and a disproportionately high recovery from the pons and midbrain, compared to animals which were killed. The data suggest that the death mechanism was brain stem ischemia followed by a vasomotor ischemic reflex, which in turn resulted in vasospasm and hypertension. The choroid plexus was found to be the most efficient filter for fat emboli within the brain on a per gram basis.

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