Formation of substituted 1-Benzazepine-2,5-diones from derivatives of kynurenine
- 1 January 1978
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 31 (2) , 439-443
- https://doi.org/10.1071/ch9780439
Abstract
Several N-protected DL-kynurenine derivatives have been converted into 3-substituted 3,4-dihydro-1H-1-benzazepine-2,5-diones by thermal cyclization. This reaction was found to proceed less readily than the analogous formation of 1,4-benzodiazepine-2,5-diones from o- aminobenzoylamino acids. The incidence of specific peptide bond cleavage involving these cyclizations was investigated with model compounds.Keywords
This publication has 2 references indexed in Scilit:
- Central nervous system active compounds. I. The synthesis of some caprolactam derivatives substituted at N1, C2 and C3Australian Journal of Chemistry, 1976
- A synthesis of some model kynurenine peptidesAustralian Journal of Chemistry, 1976