Deregulation of Interleukin-2 Receptor Gene Expression in HTLV-I-Induced Adult T-Cell Leukemia
- 7 June 1985
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 228 (4704) , 1215-1217
- https://doi.org/10.1126/science.2988127
Abstract
Infection of human T cells by human T-lymphotropic virus, type I (HTLV-I), a retrovirus, is uniformly associated with the constitutive expression of large numbers of cellular receptors for interleukin-2 (IL-2). Comparison with normal T cells shows that neither IL-2 receptor gene organization nor IL-2 receptor messenger RNA processing are altered in the leukemic cells. However, mitogenic stimuli activate IL-2 receptor gene expression in normal T cells, whereas these stimuli paradoxically inhibit IL-2 receptor gene transcription in HTLV-I-infected leukemic T cells.This publication has 21 references indexed in Scilit:
- Localization of the Gene Encoding the Human Interleukin-2 Receptor on Chromosome 10Science, 1985
- Molecular cloning and expression of cDNAs for the human interleukin-2 receptorNature, 1984
- Molecular cloning of cDNA encoding human interleukin-2 receptorNature, 1984
- Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected CellsScience, 1984
- T-Cell Growth Factor Gene: Lack of Expression in Human T-Cell Leukemia-Lymphoma Virus-Infected CellsScience, 1984
- Isolation and Transmission of Human Retrovirus (Human T-Cell Leukemia Virus)Science, 1983
- T cell growth factor receptors. Quantitation, specificity, and biological relevanceThe Journal of Experimental Medicine, 1981
- Antibodies in human sera reactive against an internal structural protein of human T-cell lymphoma virusNature, 1981
- Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaProceedings of the National Academy of Sciences, 1980
- Selective in Vitro Growth of T Lymphocytes from Normal Human Bone MarrowsScience, 1976