EFFECT OF ADRENAL CORTICAL EXTRACT, CORTISONE AND HYDROCORTISONE UPON THE WORK OF THE ADRENALECTOMIZEDEVISCERATE RAT

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Abstract
Consideration has been given to the hypothesis that cortisone must be chemically modified in the liver before it manifests hormonal activity (Ralli, 1952). The data of the present study show that adrenal cortical extract, cortisone and hydrocortisone are each capable of increasing the work output of the adrenalectomized-eviscerate rat. methods Male rats of the Sprague-Dawley strain from the Upjohn breeding colony were maintained on a diet of Archer Dog Pellets. The technique of evisceration, which is done, in two stages, has been described (Ingle, 1949). When the animals reached 250 ± 2 gm. they were anesthetized (intraperitoneal injection of 18 mg. of cyclopal sodium) and were subjected to the second stage of the operation in which the adrenal glands were removed with the other intra-abdominal organs. The stimulation of muscle was started immediately following evisceration. The procedure was according to Ingle (1944) with the following modifications.