European multi-centre comparison of thallium 201 and technetium 99m methoxyisobutylisonitrile in ischaemic heart disease

1 December 1990

journal article
research article
Published by Springer Nature in European Journal of Nuclear Medicine and Molecular Imaging

Vol. 16 (12) , 869-872
https://doi.org/10.1007/bf01280254

Abstract

Fifty-six patients in Europe were entered into a multi-centre study to compare the accuracy of technetium 99m methoxyisobutylisonitrile (^99mTc-MIBI) for the detection of coronary artery disease (CAD) with thallium 201 (²⁰¹T1) chloride perfusion scanning. The results showed a high degree of concordance between the two radiopharmaceuticals. Some 81% (678/840) of myocardial segments showed the same result (normal, infarct or ischaemia), and 80% (45/56) of patients had the same diagnosis. Overall detection of CAD in patients was 98% for²⁰¹T1 and 96% for^99mTc-MIBI. Detection of CAD in total arteries was 68% for both agents. In this study^99mTc-MIBI was as accurate as²⁰¹T1 for the detection of coronary artery stenoses.

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