BLOOD KETONES AND SERUM LIPIDS IN STARVATION AND WATER DEPRIVATION 123

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Abstract
A study has been made of the serum lipids and blood ketones of fasting adult human < dogs, and monkeys. Dogs developed no appreciable ketosis and no lipemia. In men, blood ketones increased progressively throughout the periods of starvation, 2 to 6 days. Serum cholesterol rose slightly, but unequivocally, as fasting was prolonged; lipid phosphorus rose perceptibly; neutral fat changes were equivocal. In monkeys, both blood ketones and serum lipids rose more rapidly and higher than they did in men. Again cholesterol was most affected, neutral fat did not change appreciably. In both man and monkey, the hyperlipemia was abolished by adm. of sufficient carbohydrate to mitigate or to extinguish the ketosis. From this and other evidence, it is suggested that the lipemia of carbohydrate starvation arises not merely because a larger quantity of fat is being utilized, but because an unusually large amt. of fat is being converted to ketone bodies.

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