Differentiation of Lens Tissue from the Progeny of Chick Retinal Pigment Cells Cultured In Vitro : A Demonstration of a Switch of Cell Types in Clonal Cell Culture
- 1 May 1973
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 70 (5) , 1495-1499
- https://doi.org/10.1073/pnas.70.5.1495
Abstract
Clonal cell lines isolated from the pigmented retina of 8.5-day chick embryos initially retained the capacity to form pigment. After several passages, however, many cells lost pigment granules and differentiated into lens-like structures. The lens-specific nature of the structures formed in cultures originally derived from retinal pigment cells was established by both ultrastructural and immunological studies.Keywords
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