HUMAN T CELL RESPONSE TO HERPES SIMPLEX VIRUS ANTIGEN IN VITRO
- 1 November 1980
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Section C Immunology
- Vol. 88C (1-6) , 31-38
- https://doi.org/10.1111/j.1699-0463.1980.tb00069.x
Abstract
Herpes simplex virus type I antigen (HSV-Ag) added to T cells from individuals with clinical history of recurrent herpes labialis causes a proliferative response in vitro. This T cell response requires presensitization of the responding cell donor and will occur only in the presence of adherent cells (macrophages). The intensity of the response is closely related to the number of adherent cells present, being optimal at a ratio of 10:1 between T cells and adherent cells. Preliminary studies also indicate that the response to HVS-Ag is restricted by the HLA-D/DR determinants of the T cell donor.Keywords
This publication has 12 references indexed in Scilit:
- Macrophage/T‐Lymphocyte Interaction in the Immune Response to PPD in HumansScandinavian Journal of Immunology, 1979
- In Vitro Sensitization of Human T Lymphocytes to Hapten (TNP)‐Conjugated and Non‐treated Autologous Cells is Restricted by Self‐HLA‐DScandinavian Journal of Immunology, 1979
- MHC matching shows that at least two T-cell subsets determine resistance to HSVNature, 1979
- Serological typing of HLA-D: Predictive value in mixed lymphocyte cultures (MLC)Immunogenetics, 1978
- Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H‐2‐Restriction‐Specificity and in H‐2 Linked Ir Gene ControlImmunological Reviews, 1978
- Defective in vitro lymphoproliferative responses to herpes simplex virus in patients with frequently recurring herpes infections during the disease-free intervalClinical Immunology and Immunopathology, 1978
- HLA-D Restriction of the Macrophage-Dependent Response of Immune Human T Lymphocytes to PPD in Vitro: Inhibition by Anti-HLA-DR AntiseraScandinavian Journal of Immunology, 1978
- Sequential Changes in T and B Lymphocyte Responses to Herpes Simplex Virus in ManScandinavian Journal of Immunology, 1978
- Macrophage‐Dependent Response of Immune Human T Lymphocytes to PPD In Vitro Influence of HLA‐D HistocompatibilityScandinavian Journal of Immunology, 1977
- Isolation of human T and B lymphocytes by rosette formation with 2-aminoethylisothiouronium bromide (AET) — Treated sheep red blood cells and with monkey red blood cellsJournal of Immunological Methods, 1976