‘Active’ conformation of the inositol monophosphatase substrates adenosine 2′-phosphate and inositol phosphate: role of the ribofuranosyl O-atom and inositol O-atoms in chelating a second magnesium ion
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 9,p. 1139-1141
- https://doi.org/10.1039/c39940001139
Abstract
A high energy conformation, in which the adenine moiety of adenosine 2′-phosphate occupies a C-1′-axial ribofuranosyl position, is stabilised through the chelation of a second (additional) Mg2+ ion by the 2′-and furanose ring O-atoms; with inositol 1-phosphate as the substrate, the 1- and 6-O-atoms chelate the second Mg2+ ion and for both substrates a different (buried) Mg2+ ion interacts directly with the phosphate moiety.Keywords
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