Edema: A Delayed Complication of Total-Body 32-Mev Proton Irradiation

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Abstract
In previous experiments severe edema of the head and, to a lesser degree, edema of the anterior abdominal wall and perineum had occurred approximately 8 weeks after 32-Mev proton irradiation. For the present study, a group of 11 primates were irradiated with a large dose of 32-Mev protons (2350 rads); some of the animals were treated with antibiotics in an effort to decrease mortality during periods of acute cutaneous infection. Of the original 11 irradiated animals, the 5 survivors of the acute effects of the radiation developed edema. Several diagnostic studies suggest that increased capillary and/or lymphatic permeability in conjunction with a moderate hypoalbuminemia is probably the etiology of the edema.

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