THE LONG-TERM CLONIDINE TREATMENT INDUCED BEHAVIORAL DEPRESSION IN RATS
- 1 September 1990
- journal article
- research article
- Vol. 42 (5) , 409-415
Abstract
Effects of acute and long term clonidine treatment on motor and exploratory activities in rats were investigated in the presence and absence of imipramine. Rats received saline (control), clonidine HCl (0.8 mg/kg), imipramine HCl (30 mg/kg) and clonidine in combination with imipramine for 15 days. Clonidine caused hypoactivity and loss of interest and investment in the environment both acutely (on day 1) and chronically (on day 15). These effects of clonidine were reversed by acute and chronic imipramine pretreatments. Chronic clonidine treatment seemed more suitable in producing a model for depression in rats.This publication has 14 references indexed in Scilit:
- Behavioural despair in rats: A new model sensitive to antidepressant treatmentsPublished by Elsevier ,2002
- Lesion of serotonergic neurons antagonizes clonidine-induced suppression of avoidance behavior and locomotor activity in ratsPsychopharmacology, 1981
- β-adrenergic supersensitivity in rat brainstem during clonidine withdrawalLife Sciences, 1980
- Chronic effects of miaserin on noradrenaline metabolism in the rat brain: Evidence for a pre-synaptic ?-adrenolytic action in vivoPsychopharmacology, 1979
- Depression of exploratory activity by clonidine in rats as a model for the detection of relative pre- and postsynaptic central noradrenergic receptor selectivity of ?-adrenolytic drugsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1979
- Effect of clonidine, amphetamine, and their combinations on the locomotor activity of CD-1 and C57BL/6 micePharmacology Biochemistry and Behavior, 1978
- Depression by clonidine of shaking behaviour elicited by nalorphine in morphine-dependent ratsJournal of Pharmacy and Pharmacology, 1977
- Catecholamine receptors on locus coeruleus neurons: Pharmacological characterizationEuropean Journal of Pharmacology, 1977
- Are central cholinergic paths involved in habituation of exploration and distraction?Pharmacology Biochemistry and Behavior, 1976
- Different alpha-adrenoreceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agentsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1976