CO 2 REQUIREMENTS AND NUCLEIC ACID SYNTHESIS BY BRUCELLA ABORTUS

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Abstract
-A strain of B. abortus which requires an increased pCO2 in air for growth and a mutant strain which does not require an increased pCO2 were compared with respect to the manner in which they synthesize nucleic acids from C14O2 and C14-labeled purine and pyrimidine bases. No differences were noted in the nucleic acid metabolism of these strains. Both strains fix C14O2 primarily into nucleic acid pyrimidines, assimilate exogenous purines and pyrimidines, and incorporate C14 from these bases into nucleic acid constituents.