ROLE OF LIPOPOLYSACCHARIDE IN PRODUCTION OF PLASMA-CELL TUMORS IN MICE GIVEN MINERAL-OIL INJECTIONS
- 1 January 1978
- journal article
- research article
- Vol. 38 (3) , 703-705
Abstract
The lipopolysaccharide (LPS) content of peritoneal fluids of BALB/c mice given mineral oil injections and normal mice was measured. Peritoneal fluids were passed through DEAE-Bio-Gel columns to remove an inhibitor to the Limulus amebocyte lysate reaction and then were assayed for LPS by a spectrophotometric Limulus amebocyte lysate test. A highly significant difference between control animals and animals given mineral oil injections was found. A clear correlation between LPS concentration and time after 1st oil injection was shown. P-200 gel chromatography and heat stability of the active material were consistent with the behavior of LPS. The possible role of LPS in the pathogenesis of plasma cell tumors is discussed.This publication has 4 references indexed in Scilit:
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- ENDOTOXIN ENHANCEMENT OF PLASMA-CELL TUMOR DEVELOPMENT IN MICE GIVEN INJECTIONS OF MINERAL-OIL1976
- STUDIES ON PATHOGENESIS OF PLASMA CELL TUMORS .I. EFFECT OF CORTISOL ON DEVELOPMENT OF PLASMA CELL TUMORS1966
- STUDIES ON PATHOGENESIS OF PLASMA CELL TUMORS .2. ROLE OF MAST CELLS AND PITUITARY GLYCOPROTEIN HORMONES IN INHIBITION OF PLASMA CELL TUMORIGENESIS1966