Tetrocarcins, new antitumor antibiotics. 3. Antitumor activity of tetrocarcin A.
- 1 January 1982
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 35 (8) , 1033-1037
- https://doi.org/10.7164/antibiotics.35.1033
Abstract
Tetrocarcin A, isolated from a Micromonospora culture, showed activity against experimental i.p. inoculated tumors such as Ehrlich carcinoma, MH134 hepatoma and B16 melanoma. It was not active against solid tumors, such as sarcoma 180 and Ehrlich carcinoma. It was marginally active against the growth of solid Lewis lung carcinoma, without prolonging the life span of the tumor-bearing mice. It was active against P388 leukemia (i.v.-i.v. system). It did not show myelosuppression and nephrotoxicity in mice. DNA and protein synthesis of P388 cells in culture were more significantly suppressed than RNA synthesis by tetrocarcin A.This publication has 3 references indexed in Scilit:
- Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity.The Journal of Antibiotics, 1980
- Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity.The Journal of Antibiotics, 1980
- Direct enzymatic determination of urea in plasma and urine with a centrifugal analyzer.Clinical Chemistry, 1976