Cytotoxicity of Cinnamic Aldehyde on Leukemia L1210 Cells
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Drug and Chemical Toxicology
- Vol. 6 (6) , 521-535
- https://doi.org/10.3109/01480548309017807
Abstract
Cytotoxic effect of cinnamic aldehyde (CA) on L1210 mouse leukemia cells was tested. Addition of CA in Fischer's medium at 4.8 μg/ml could inhibit the growth of L1210 by 50 per cent. The terminal aldehyde-group of CA molecule was found to be responsible to the inhibition.Experiments of incorporating [3H]-uridine, [3H] -thymidine, and [3H]-leucine by the cells revealed that the syntheses of protein, DNA, and RNA were suppressed by the presence of CA in the culture solution with potency appeared in that order. The inhibitory effect of CA on glycolysis was insignificant. Direct reaction between aldehyde-groups of CA molecules and sulf-hydryl-groups of cell components was proved. The results suggested that CA inhibited L1210 cells by blocking protein synthesis through trapping sulfhydryl-containing amino acids in the cell.This publication has 17 references indexed in Scilit:
- Antifungal Activity of Components of Essential OilsAgricultural and Biological Chemistry, 1981
- Antifungal Activity and Molecular Orbital Energies of Aldehyde Compounds from Oils of Higher PlantsAgricultural and Biological Chemistry, 1979
- Selective inhibitory effect of benzaldehyde on the growth of Simian virus 40-transformed cellsBiochemical and Biophysical Research Communications, 1979
- INHIBITION OF GROWTH AND AFLATOXIN PRODUCTION BY CINNAMON AND CLOVE OILS. CINNAMIC ALDEHYDE AND EUGENOLJournal of Food Science, 1977
- Studies on the anti-tumour activity of aliphatic aldehydes—V.: Preferential inhibition of protein synthesis in normal or neoplastic tissues in relation to molecular structurePublished by Elsevier ,1972
- Studies on the anti-tumour activity of aliphatic aldehydes—III: Formation of thiazoidine-4-carboxylic acid in tissuesPublished by Elsevier ,1971
- Food flavourings and compounds of related structure. II. Subacute and chronic toxicityFood and Cosmetics Toxicology, 1967
- Studies on the anti-tumour activity of aliphatic aldehydes — I: The mechanism of inhibition of amino acid incorporation into protein of Yoshida ascites hepatoma cellsEuropean Journal of Cancer (1965), 1965
- Food flavourings and compounds of related structure I. Acute oral toxicityFood and Cosmetics Toxicology, 1964
- Tissue sulfhydryl groupsArchives of Biochemistry and Biophysics, 1959