Organotypic Bioelectric Activity in Cultured Reaggregates of Dissociated Rodent Brain Cells
- 14 April 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4031) , 182-184
- https://doi.org/10.1126/science.176.4031.182
Abstract
Complex repetitive-spike or slow-wave discharges can be evoked, and can also occur spontaneously, in small clusters of neurons which reaggregate in vitro after dissociation of cerebral cortex, brainstem, or spinal cord from the fetal mouse. Even after random dispersion in culture, these cells still form functional synaptic networks with bioelectric discharge patterns and pharmacologic sensitivities characteristic of the organ (that is, organotypic).Keywords
This publication has 22 references indexed in Scilit:
- Development of synapses and myelin in cultures of dissociated embryonic mouse spinal cord, medulla and cerebrumBrain Research, 1972
- AN ELECTRON MICROSCOPIC STUDY OF THE DEVELOPMENT OF SYNAPSES IN CULTURED FETAL MOUSE CEREBRUM CONTINUOUSLY EXPOSED TO XYLOCAINEThe Journal of cell biology, 1971
- Electron microscopic analysis of aggregation of embryonic cells: the structure and differentiation of aggregates of neural retina cellsDevelopmental Biology, 1970
- Synaptic Potentials Recorded in Cell Cultures of Nerve and MuscleScience, 1970
- Histogenesis of fetal mouse isocortex and hippocampus in reaggregating cell culturesDevelopmental Biology, 1970
- Bioelectric interactions between cultured fetal rodent spinal cord and skeletal muscle after innervation in vitroJournal of Experimental Zoology, 1970
- Onset and development of functional interneuronal connections in explants of rat spinal cord-ganglia during maturation in cultureBrain Research, 1967
- The onset of synapse formation in spinal cord cultures as studied by electron microscopyBrain Research, 1967
- Bioelectric Activity in Long-Term Cultures of Spinal Cord TissuesScience, 1963
- Inhibitory Phasing of Neuronal DischargeNature, 1962