Comparative Study of Hemagglutination and Agglutination Tests for the Determination of the Antibody Response of Patients withShigella SonneiDysentery

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Abstract
A comparative study of the sensitivities of the Shigella sonnei agglutination and hemagglutination tests for the detection of antibodies in patients with dysentery and their family contacts revealed the following. (1) The antibody titers detected by means of the hemagglutination method were usually higher than those revealed by means of the agglutination test; however, there was no constant ratio between agglutinln and hemagglutlnln titers; the ratios ranged from 1:4 to 1:64 in titrations of 70 of 90 serum specimens. (2) The hemagglutination method proved to be more sensitive when compared with agglutination tests utilizing heated, formalinized, and alcohol-treated bacterial suspensions of the identical strain. (3) Significant increase in antibody titers during dysentery was revealed more frequently by means of the hemagglutination than by the agglutination procedure.