A convenient and rapid synthesis of potassium penicilliantes using EEDQ
- 1 April 1979
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 16 (3) , 621-622
- https://doi.org/10.1002/jhet.5570160347
Abstract
N‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ, 1) has been utilized as a coupling reagent to attach sterically unhindered acids to the potassium salt of 6‐aminopenicillanic acid (4) at room temperature.The excellent yields and rapidity of the reaction illustrate the convenience of utilizing 1 as the coupling reagent to directly prepare the potassium salt of certain penicillins.This publication has 4 references indexed in Scilit:
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- Nuclear analogs of β-lactam antibiotics. VIII. Synthesis of 3-acetoxymethyl-Δ3-O-2-isocephemsCanadian Journal of Chemistry, 1978
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- Derivatives of 6-Aminopenicillanic Acid. I. Partially Synthetic Penicillins Prepared from α-Aryloxyalkanoic AcidsJournal of the American Chemical Society, 1960