ANTIBODY-DEPENDENT CELLULAR CYTO-TOXICITY MEDIATED BY SUB-POPULATIONS OF HUMAN LYMPHOCYTES-T - KILLING OF HUMAN-ERYTHROCYTES AND AUTOLOGOUS LYMPHOID-CELLS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 39  (3) , 407-416
Abstract
The cytotoxic capabilities of human T [thymus-derived] lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells were characterized in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin(Ig)G (TG) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (TM) displayed no ADCC activity. TG cell-mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig Null cells and low-affinity E[erythrocyte]-rosette forming cells were also capable of similar ADCC activity against these targets.

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