Placental Transfer of Mo99 and Ca45 in Swine

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Abstract
A study has been made to determine the extent to which molybdenum and calcium were transferred to the developing fetus in Duroc swine using the Mo99 and Ca45 isotopes. Mo99 was readily absorbed after oral administration to the sows and widely distributed in their tissues. Little or none was found in the various tissues of the fetuses, indicating a placental barrier to this element. Ca45 was readily transferred to the developing fetus and a greater percentage of it was found in the fetal bones per unit of weight than in the bones of the sows. No significant differences were observed in the uptake and distribution of the Mo99 and Ca45 isotopes between sows in their first and second pregnancies. Approximately 55% of the orally administered labelled molybdenum was excreted in the urine and 8% in the feces within 30 hours. Approximately half the intake of Ca45 was excreted in the feces and only a trace in the urine during the corresponding period.

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