Placental Transfer and Deposition of Labeled Calcium in the Developing Bovine Fetus

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Abstract
Data are presented showing the uptake and turnover of labeled Ca in the dam and 8-mo. fetus at 10 min., 8 hrs:, 30 hrs. and 168 hrs. after intraven. injn. into the pregnant bovine, and similarly in the 3.5-mo., 6-mo., 7.5-mo. and 8.5-mo.-old fetus at 7 days after oral admn. to the pregnant bovine. Ca, P and ash values are also reported. There was relatively free movement of Ca45 across the placenta. Equilibrium of Ca between blood of fetus and dam was not observed until some time after it had been attained between blood and soft tissues of the dam, suggesting the existence of some degree of barrier. The fetal bones showed a greater uptake of Ca45 and turnover than did the maternal bones. The progression of mineralization in the fetal bones was at a max. some time between the 4th and 7th mo. as indicated both by the uptake of Ca45 and the analytical values.