Abnormalities in the regulation of growth hormone in chronic renal failure

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Abstract
Carbohydrate intolerance is a common abnormality in patients with chronic renal failure. In this group of patients the interrelation among glucose, insulin and growth hormone [GH] was investigated. The presence of carbohydrate intolerance and hyperinsulinemia was confirmed. Alterations in GH regulation, characterized by the lack of suppression of GH by orally induced hyperglycemia and paradoxical increase in serum levels of GH after the administration of i.v. glucose or glucagon; lack of release of GH with induced hypoglycemia and an exaggerated response to levodopa administration were demonstrated. Thyrotropin-releasing hormone stimulated GH release, a phenomenon not observed in the control population. The studies show an impaired hypothalamic regulation of GH secretion in patients with renal failure undergoing long-term hemodialysis.

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