TOXICITY OF 1, 2‐DIMETHYLHYDRAZINE IN MICE: EFFECT OF DIET AND DEVELOPMENT OF TOLERANCE
- 1 September 1985
- journal article
- Published by Wiley in Journal of Food Safety
- Vol. 7 (2) , 77-81
- https://doi.org/10.1111/j.1745-4565.1985.tb00499.x
Abstract
The effect of diet on the lethality of 1, 2‐dimethylhydrazine (DMH) injections was investigated using Swiss mice. Mortality was highest when mice were fed a nutrient‐diluted/high‐fat diet, was intermediate with a nutrient‐diluted/low‐fat diet and was lowest with laboratory chow. Wheat bran was not protective. Mice developed tolerance to DMH after receiving several injections of progressively increasing dose.Keywords
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