Inhibition of DNA polymerase alpha by aphidicolin derivatives
Open Access
- 1 January 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (11) , 5107-5113
- https://doi.org/10.1093/nar/16.11.5107
Abstract
17-Acetylaphidicolin was 10-fold weaker and two derivatives lacking hydroxyl groups at the 16 and 17 positions were 100-fold weaker than aphidicolin as inhibitors of DNA polymerase α from HeLa and Chinese hamster ovary cells. 17,18-Diacetyl, 3,17,18-triacetyl and 3-epi derivatives of aphidicolin were inactive. Active compounds were, like aphidicolin, competitive with dCTP and did not inhibit aphidicolin-resistant DNA polymerases.This publication has 19 references indexed in Scilit:
- Identification of DNA polymerase .delta. in CV-1 cells: studies implicating both DNA polymerase .delta. and DNA polymerase .alpha. in DNA replicationBiochemistry, 1987
- Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase .ALPHA. in vitro.CHEMICAL & PHARMACEUTICAL BULLETIN, 1986
- Purification and characterization of DNA polymerase alpha of chinese hamster ovary cellsMolecular and Cellular Biochemistry, 1985
- Inhibition of RNA-directed DNA polymerase from avian myeloblastosis virus by a 5-benzyl-6-aminouracilBiochemical and Biophysical Research Communications, 1985
- DNA polymerase .delta.: one polypeptide, two activitiesBiochemistry, 1982
- Specific and reversible inhibition by aphidicolin of the α‐like DNA polymerase of plant cellsFEBS Letters, 1980
- Effect and mechanism of action of aphidicolin on yeast deoxyribonucleic acid polymerasesAntimicrobial Agents and Chemotherapy, 1980
- The mode of action of aphidicolin on DNA synthesis in isolated nucleiBiochemical and Biophysical Research Communications, 1980
- Inhibition of DNA synthesis in the adenovirus DNA replication complex by aphidicolin and 2′,3′-dideoxythymidine triphosphateBiochemical and Biophysical Research Communications, 1980
- Aphidicolin: A specific inhibitor of DNA polymerases in the cytosol of rat liverBiochemical and Biophysical Research Communications, 1978