Enantioselective Binding of an 11-cis-Locked Cyclopropyl Retinal. The Conformation of Retinal in Bovine Rhodopsin
- 24 May 1999
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 1 (1) , 51-54
- https://doi.org/10.1021/ol990048l
Abstract
The conformation of the retinal chromophore in rhodopsin is central for understanding the visual transduction process. The absolute twist around the 12-s bond of the chromophore in rhodopsin has been determined by studies with 11-cis-locked 11,12-cyclopropylretinal analogues (11S,12R)-2 and (11R,12S)-3, enantioselectively synthesized with the aid of an enzyme. The finding that enantiomer 2 binds to opsin while the other 3 does not defines the absolute sense of twist around the 12-s bond.Keywords
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